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The Clinical Functional Genomics Laboratory (CFG) utilizes the modern tools of neuroscience to help understand the effects that risk forms of genes have on brains structure and function. Modalities include comprehensive assessment of clinical symptomatology, neurocognitive testing, and structural and functional brain imaging. Over the past several years, the CFG has been responsible for studies implicating the schizophrenia susceptibility gene, dysbindin, in general cognitive ability in healthy volunteers and patients with schizophrenia, detecting a role for a key cancer gene, MET, in schizophrenia and cognition, and implicated a specific polymorphism in the brain-derived neurotrophic factor (BDNF) gene in the volume of a critical region, the hippocampus, of the brain. The CFG is now expanding to incorporate gene expression assays of peripheral and central nervous system tissue, as well as animal models of learning and behavior.
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Staff at the Lab: Szeszko, Philip R. Ph.D Associate Investigator The Zucker Hillside Hospital, Department of Psychiatry Research szeszko@lij.edu 718-470-8489 FF: 718-343-1659 Burdick, Katherine E. Ph.D Assistant Investigator The Zucker Hillside Hospital, Department of Psychiatry Research kateburdick@lij.edu 718-470-8167 Goldberg, Terry Ph.D Director, Research–Neuropsychology The Zucker Hillside Hospital, Department of Psychiatry Research Tgoldber@nshs.edu 718-470-8151 Gallego, Juan M.D Assistant Investigator The Zucker Hillside Hospital, Department of Psychiatry Research Jgallego1@nshs.edu 718-470-8177 | |
