Pharmacogenetics in Psychiatry


(Click on any title to open publication in pdf format)

Selected Publications 2007-2009:

Goldberg TE, Kotov R, Lee AT, Gregersen PK, Lencz T, Bromet E, Malhotra AK. (2009) The serotonin transporter gene and disease modification in psychosis: Evidence for systematic differences in allelic directionality at the 5-HTTLPR locus. Schizophrenia Research, 111(1-3),103-8. Epub: 2009 Apr 8. 

Lencz T, Lipsky RH, DeRosse P, Burdick KE, Kane JM, Malhotra AK. (2009). Molecular differentiation of schizoaffective disorder from schizophrenia using BDNF haplotypes. British Journal of Psychiatry, 194(4), 313-318. 

Neuhaus AH, Goldberg TE, Hassoun Y, Bates JA, Nassauer KW, Sevy S, Opgen-Rhein C, Malhotra AK. (2009) Acute dopamine depletion with branched chain amino acids decreases auditory top-down event-related potentials in healthy subjects. Schizophrenia Research,111(1-3),167-73. Epub 2009 Apr 7. 

DeRosse P, Lencz T, Burdick KE, Kane JM, Malhotra AK. (2008) The genetics of symptom-based phenotypes: Towards a molecular classification of schizophrenia. Schizophrenia Bulletin, 34(6), 1047-1053. Epub: 2008 July 15. 

Opgen-Rhein C, Lencz T, Burdick KE, Neuhaus AH, Goldberg TE, Malhotra AK. (2008) Genetic variation in the DAOA gene complex: Impact on susceptibility for schizophrenia and on cognitive performance. Schizophrenia Research, 103(1-3), 169-177. Epub: 2008 June 9. 

Burdick KE, Kamiya A, Hodgkinson CA, Lencz T, DeRosse P, Elashvili S, Kane JM, Goldman D, Sawa A, Malhotra AK. (2008). Elucidating the relationship between DISC1, NDEL1, and NDE1 and the risk for schizophrenia: Evidence of epistasis and competitive binding. Human Molecular Genetics, 17(16), 2462-73. Epub: 2008 May 10. 

Szeszko PR, Hodgkinson CA, Robinson DG, Derosse P, Bilder RM, Lencz T, Burdick KE, Napolitano B, Betensky JD, Kane JM, Goldman D, Malhotra AK. (2007/2008) DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophrenia. Biological Psychology, 79(1), 103-10. Epub: 2007 Nov 1. 

Lencz T, Lambert C, DeRosse P, Burdick KE, Morgan TV, Kane JM, Kucherlapati R, Malhotra AK. (2007) Runs of homozygosity reveal highly penetrant recessive susceptibility loci in schizophrenia. Proceedings of the National Academy of Sciences USA, 104(50), 19942-47. E-pub: 2007 Dec 05. 

Lencz T, Morgan TV, Athanasiou M, Dain B, Reed CR, Kane JM, Kucherlapati R, Malhotra AK. (2007) Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia. Molecular Psychiatry, 12(6), 502-509. Epub: 2007 Mar 20. 

Burdick KE, Goldberg TE, Funke B, Bates JA, Lencz T, Kucherlapati R, Malhotra AK. (2006/2007) DTNBP1 genotype influences cognitive decline in schizophrenia. Schizophrenia Research, 89(1-3), 169-72. Epub: 2006 Oct 30. 

DeRosse P, Hodgkinson CA, Lencz T, Burdick KE, Kane JM, Goldman D, Malhotra AK. (2006) Disrupted in Schizophrenia 1 (DISC1) Genotype and positive symptoms in schizophrenia. Biological Psychiatry, 61(10), 1208-10. Epub: 2006 Oct 18. 

DeRosse P,  Funke B, Burdick KE, Lencz T,  Kane JM, Kucherlapati R, Malhotra AK. (2006) COMT genotype and manic symptoms in schizophrenia. Schizophrenia Research, 87(1-3), 28-31. Epub: 2006 Jul 7. 

Lencz T, Robinson DG, Xu K, Ekholm J, Sevy S, Gunduz-Bruce H, Woerner MG, Kane JM, Goldman D, Malhotra AK. (2006) DRD2 promoter region variation as a predictor of sustained response to antipsychotic medication in first-episode schizophrenia patients. American Journal of Psychiatry, 163(3), 529-531. 

DeRosse P,  Funke B, Burdick KE, Lencz T, Ekholm JM, Kane JM, Kucherlapati R, Malhotra AK. (2006) Dysbindin (DTNBP1) genotype and negative symptoms in schizophrenia. American Journal of Psychiatry, 163(3), 532-534. 

Burdick KE, Lencz T, Funke B, Finn CT, Szeszko PR, Kane JM, Kucherlapati R, Malhotra AK. (2006) Genetic variation in DTNBP1 influences general cognitive ability. Human Molecular Genetics, 15(10), 1563-1568; Epub: 2006 Jan 13. 

Szeszko PR, Lipsky R, Mentschel C, Robinson D, Gunduz-Bruce H, Sevy S, Ashtari, M, Napolitano B, Bilder RM, Kane JM, Goldman D, Malhotra AK. (2005) Brain-derived neurotrophic factor val66met polymorphism and volume of the hippocampal formation, Molecular Psychiatry, 10(7),, 631-6. 

Hodgkinson CA, Goldman D, Jaeger J, Persaud S, Kane JM, Lipsky RH, Malhotra AK. (2004) Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder. Am J Hum Genet, 75(5),862-72. Epub 2004 Sep 22. 

Funke B, Finn CT, Plocik AM, Lake S, DeRosse P, Kane JM, Kucherlapati R, Malhotra AK. (2004) Association of the DTNBP1 locus with schizophrenia in a U.S. population. Am J Hum Genet, 75(5), 891-8. Epub 2004 Sep 10. 

Malhotra AK, Murphy GM Jr, Kennedy JL. (2004) Pharmacogenetics of psychotropic drug response. Am J Psychiatry, 161(5),780-96.